3D Feature Viewer for UniProt

Map UniProt residue annotations, variants, ligand context, and precomputed variant-effect evidence onto 3D protein structures.

3D Feature Viewer for UniProt adds an interactive structure viewer to every UniProt protein page. Instead of copying residue numbers into a separate program, you click a button and the 3D structure opens beside the annotation you are already reading — with everything already mapped onto it. What you can do: View disease-causing mutations, post-translational modifications, active sites, and domain boundaries on the structure in one click Switch between AlphaFold predicted models and experimental PDB structures without leaving the page Click any residue to see its full annotation history: clinical variant classifications, predicted effect scores (AlphaMissense, EVE, ESM-1b, FoldX ΔΔG, CADD, conservation), nearby residues, and binding pocket evidence Explore candidate binding pockets and transplanted ligands from AlphaFill Check drug tractability data from Open Targets right in the viewer Export annotated residue tables as CSV, or download ready-to-run session scripts for PyMOL and VMD Works out of the box. No account, no login, no data uploaded anywhere. The extension fetches everything from public scientific databases (UniProt, PDBe, AlphaFold DB, ProtVar, Open Targets) and displays it locally in your browser. Free and open source. See the full user guide on GitHub.